UDM is comprised of eight colleges: the School of Architecture, College of Business Administration, School of Dentistry, College of Engineering and Science, College of Health Professions, School of Law, College of Liberal Arts and Education, McAuley School of Nursing.

There are two main campuses, as well as the School of Law which is located in downtown Detroit at 651 East Jefferson across from the Renaissance Center. McNichols Campus is located in northwest Detroit, on the southeast corner of McNichols and Livernois, at 4001 West McNichols; it is the original University of Detroit campus and is marked architecturally by the University Clock Tower, a structure built as a memorial to U of D students lost in World War I. Calihan Hall, home of the UDM Titans women’s and men’s basketball teams, as well as student residences are located on this campus. Outer Drive Campus is located at 8200 West Outer Drive only a short drive from McNichols. It is the location of the School of Dentistry, and UDM Conference Centre.

The McNichols campus is located in a well established residential section of Detroit and provides safe and reasonable near-by off-campus housing. Nevertheless, Detroit is not a uniformly safe urban environment. Detroit’s downtown, Cultural Center and New Center areas are not easily accessible for most UDM students. Areas of urban decay- and urban renewal- separate the campus from these important points of interest. However, the suburban communities to the north of Detroit like Hazel Park, Madison Heights, Southfield and Troy are easily accessible and rich in shopping and entertainment options. Public transit is limited; albeit, SMART buses connect UDM to suburban communities and DDOT buses travel throughout the city of Detroit.