Commonly referred to as "Transy," the school is located on a 35 acre (142,000 m²) campus about 4 blocks north of the downtown Lexington

Academic buildings

• Haupt Humanities  - The most used classroom building, it houses the various humanities programs.
• Cowgill Center  - Finished in 1999, houses the Business, Economics & Education programs.
• L.A. Brown Science Center  - Natural Sciences building. Includes largest classroom on campus, Strickland auditorium, a greenhouse, numerous labs and a nuclear magnetic resonance spectrometer.
• J. Douglas Gay Jr. / Frances Carrick Thomas Library  - The library complex includes the original Frances Carrick Thomas Library, dedicated by President Eisenhower in 1954, and the J. Douglas Gay Jr. addition, dedicated by Vice President George Bush in 1986.
• Mitchell Fine Arts Center  - Houses facilities for all of the fine arts programs. Contains a large concert hall, small theater, recital hall, art gallery and practice rooms, among other things.
• Charles L. Shearer Studio Art Building  - This building is home to most of the visual art facilities, including a dark room, ceramics, painting, and other studios, and a student art gallery.

Residential buildings

• Forrer Hall  - Mainly the women's dorm, Forrer's front and back lobbies contain offices for Residence Life, Department of Public Safety, and others.
• Clay Hall  - Men's dorm primarily for first-years.
• Davis Hall  - Men's dorm for upperclassmen. Each floor belongs to one of the four fraternities.
• Rosenthal Residence Complex  - Apartment complex for upperclassmen.
• Poole Residence Center  - Suite style residential building.
• Hazelrigg Hall  - A multipurpose building. Contains a classroom, a computer lab, social science faculty offices, and two floors of dormitories.

Other buildings

• Old Morrison  - The administrative building, this building was built in the 1830s and has burnt twice, most recently in 1969, when the interior was completely gutted. This building is featured on the city seal of Lexington.
• Lucille C. Little Theater  - Black box style theater allowing for very flexible stage and seating arrangements.
• Clive M. Beck Athletic Center  - Contains athletics offices, classrooms, fitness center, competition and recreational facilities. Completed in 2002.