Politics

• Charlie Dent, United States Congressman.
• Rick Santorum, United States Senator.

Business

• Herman Fisher, co-founder of Fisher-Price toy company
• William Schreyer, chairman emeritus and former CEO of Merrill Lynch & Co
• Frank Smeal, financier

Science

• Paul Berg, recipient of 1980 Nobel Prize in Chemistry
• Guion Bluford, first African-American in space
• Ben Cohen, co-founder of Ben & Jerry's Ice Cream
• Jerry Greenfield, co-founder of Ben & Jerry's Ice Cream
• Joel Myers, founder of AccuWeather
• Paul J. Weitz, astronaut

Art/Media

• Donald Bellisario, television producer
• Charles Bierbauer, television journalist
• Julius J. Epstein, screenwriter of Casablanca
• Carmen Finestra, television producer
• Jonathan Frakes, actor and director (Star Trek series)
• Dave Jones, former national editor for The New York Times
• Mike Reid, country music songwriter
• Lisa Salters, Reporter for ESPN and former Nittany Lady Lion Basketball Star

Athletics

• LaVar Arrington, professional football player
• Ki-Jana Carter, professional football player
• Kerry Collins, professional football player
• Roosevelt Grier, former professional football player
• Franco Harris, former professional football player
• Kelly Mazzante, professional basketball player
• Suzie McConnell Serio, former professional basketball player, current coach