Bigelow-Rice Hall  was built in 1962. Now, it is part of the Conrades•Wetherell Science Center. It houses the Botany, Microbiology and Zoology Departments at Wesleyan.

Edgar Hall  is home for the Fine Arts Center. Students there study painting, drawing,computer graphics, art history and photography (two-dimensional art).

Sturges Hall  was constructed in 1855. It served as a university library until Slocum Hall replaced it. Sturges Hall is currently the home for the English and Humanities-Classics departments. Sturges is on the National Register of Historical Places.

The University Hall  serves as a prominent landmark on campus. It is home for many administrative offices: the President's Office, Registrar's Office, Business Affairs and the Modern Foreign Languages departments.

Gray Chapel is located in The University Hall. It is the home of a $442,000 Johannes Klais Orgelbau Memorial Concert Organ with 82 ranks, 55 stops, and 4,522 pipes.

Slocum Hall  was built in 1898 and features a Romanesque arcade and enormous glass skylight. It was the University library until 1966 when Beeghly Library was built. Several administrative offices are located in the Hall: the Admissions Office, Financial Aid, Minority Student Affairs, and Foreign Student Services. Ancient, Medieval, and Renaissance Studies, Black World Studies, and Women's Studies departments are also located in Slocum Hall.

Elliot Hall  holds a significant historic place in Wesleyan University. Delaware was laid out in 1808 and became a popular health resort. Established in 1842, the University was built around the town's Mansion House (now Elliot Hall). Elliott was built in 1833 in the Greek revival style and is the original building on campus.

Currently, Elliott Hall houses Wesleyan's international studies, politics and government, history, sociology and anthropology departments. The fourth floor houses the Book Review section of The Historian, which is the official journal of Phi Alpha Theta, the international history honor society, and is one of the largest circulating English-language history periodicals. The building is also placed on the National Register of Historic Places in the U.S.

The 35-million-dollar Conrades•Wetherell Science Center  was completed in 2004. It is the home of the Botany-Microbiology, Zoology, Chemistry, Geology and Geography, Mathematics and Computer Science, and Physics and Astronomy departments.

Phillips Hall  is the home of the Psychology, Philosophy, Education, Experimental Psychology, Religion and East Asian Studies Departments. It was built in 1957. In addition to classrooms and offices, Phillips Hall also has approximately 8,000 square feet designated for empirical research and clinical observation laboratories. The annual commencement ceremony is held on the terrace of Phillips since 1958.