- 109 permanent buildings with 3.8 million square feet (353,000 m²) of space.
- 466 acres (1.9 km²)
- one mile (1.6 km) from the geographic center of Tennessee
The campus is 1.3 miles (2 km) east of downtown Murfreesboro. The oldest building on campus, Kirksey Old Main, lies at the
north end of the original quadrangle. Flanking it to the west are Rutledge Hall, a dormitory, the James Union, and Lyon and
Monohan Halls, which are also dorms. Flanking to the east are Jones Hall (now an office building), Todd Hall (the former library,
which recently underwent renovations and is now home to the Art Department), Wiser-Patten Science Hall/Davis Science Building,
and Smith, a men's' dormitory. These are the key original buildings on campus and form its historic core. Between these buildings
are Peck Hall, (English and History departments), Walnut Grove, and Cope Administration Building. Further east are newer
additions, such as the Keathley University Center, Photography Building, Ned McWherter Learning Resources Center, John Bragg Mass
Communications Building, James Walker University Library, Business and Aerospace Building, Campus Recreation Center, and the
campus' newest building, the Paul W. Martin, Sr. Honors College. In the early 2000s, nine fraternities moved to the university's
state-of-the-art Greek Row, located on the extreme eastern side of campus. Sorority Houses are prohibited per Tennessee state law. Sororities are given meeting rooms in campus buildings.All buildings on campus are given 2, 3, or 4 letter abbreviations, which most people use to identify the buildings. For
example, the Keathley University Center is better known as "The KUC". The Business and Aerospace Building is better known as "The
BAS".The campus takes the general shape of a square and is largely cut off to automobile traffic. Its borders, however, are defined
by four heavily-traveled Murfreesboro thoroughfares:
- On the west: North Tennessee Boulevard
- On the south: East Main Street
- On the east: North Rutherford Boulevard
- On the north: Greenland Drive
Middle Tennessee State University has no auxiliary campuses, and aside from online courses, all classes are held either
on-campus or at adequate facilities in the city of Murfreesboro.MTSU is only a half-mile (800 m) east of the nearest hospital, privately-owned Middle Tennessee Medical Center, located on
East Bell Street.