The campus is located in the Green Hills suburbs of Nashville between Belmont Boulevard to the west and Granny White Pike on the east.

The center of the university, known as Bison Square, is located between the Student Center and the Willard Collins Alumni Auditorium. The bricked square is traditionally used during warm weather as the location for nightly devotionals, concerts, and other campus activities. Attached to Alumni Auditorium is the Burton Bible Building where Religious, Philosophical, Mass Communications, History and Political Science classes are held. To the south side of the Burton Bible Building is the Axel Swang Center where Business and English classes are held. Other academenic buildings include the McFarland Hall of Sciences where the Science and Math classes are held.

Some academic buildings were built with public funds. One of the stipulations was that these buildings cannot have religious classes taught in them. For example, no Bible classes are taught in the McFarland Hall of Sciences. However this rule does not apply to Ward Lecture auditorium, which is attached to McFarland Hall. Construction of Ward was built through private donations.

Beaman Library was constructed in time for the university's centennial in 1991. The university's old library, the Crisman building, serves as the university's administrative building.

The university has several dormitories including Elam Hall, Fanning Hall, and Johnson Hall (all women's dormitories). Elam and Fanning are unique in design in that they have a large enclosed inner courtyard. At 8 stories tall High Rise dormitory is the university's tallest structure and the largest men's dormitory. The oldest men's dormitory is Sewell Hall, which was recently renovated in the late 1990s.

The university also boasts the Allen Arena, a 5,028-seat multipurpose facility, which opened in October 2001 on the site of the old McQuiddy Gymnasium. The adjacent student recreational center kept the McQuiddy name. Yearwood Hall, a women's dormitory, was torn down for construction of Allen Arena and its accompanying parking garage.