Government and Military

• Bruce Cole - eighth chairman of the National Endowment for the Humanities (2001-present)
• Benjamin O. Davis, Jr. - airman; first African-American to receive star in US Air Force; awarded Distinguished Flying Cross in 1943; served as Assistant Secretary of Transportation under President Nixon
• Lincoln Diaz-Balart - U.S. Representative
• Alene B. Duerk - first female rear admiral in the United States Navy
• Dennis Kucinich - U.S. Representative, and youngest person to be elected mayor of a major city (Cleveland) at age 31 (in 1977)
• Louis Stokes - former U.S. Representative
• Stephanie Tubbs Jones - U.S. Representative

Science/Technology/Medicine

• Peter C. Agre - co-winner of 2003 Nobel Prize in Chemistry, for discovery of water channels (or aquaporins) in cells
• Paul Berg - winner of the 1980 Nobel Prize in Chemistry, for biochemical characterization of recombinant DNA
• Herbert Dow - founder of Dow Chemical
• H. Jack Geiger - founding member, past president of Physicians for Social Responsibility (which shared 1985 Nobel Peace Prize as part of International Physicians for the Prevention of Nuclear War) and Physicians for Human Rights (which shared 1997 Nobel Peace Prize as part of International Campaign to Ban Landmines)
• Julie L. Gerberding - first woman director of the Centers for Disease Control and Prevention (CDC)
• Alfred Gilman - co-winner of the 1994 Nobel Prize in Physiology or Medicine, for co-discovery of G Proteins
• Donald A. Glaser - winner of the 1960 Nobel Prize in Physics, for invention of the bubble chamber
• Corneille J.F. Heymans - winner of the 1938 Nobel Prize in Physiology or Medicine for work on carotid sinus reflex
• George H. Hitchings - co-winner of the 1988 Nobel Prize in Physiology or Medicine, for research leading to development of drugs to treat leukemia, organ transplant rejection, gout, herpes virus, and AIDS-related bacterial and pulmonary infections
• Donald Knuth - foremost computer scientist
• Polykarp Kusch - winner of the 1955 Nobel Prize in Physics, for determining the magnetic moment of the electron
• Paul C. Lauterbur - co-winner of the 2003 Nobel Prize in Physiology or Medicine, for discoveries leading to creation of Magnetic Resonance Imaging
• John J.R. Macleod - co-winner of the 1923 Nobel Prize in Physiology or Medicine, for discovery of insulin
• Albert A. Michelson - winner of the 1907 Nobel Prize in Physics for disproving existence of "ether"; first American to receive a Nobel Prize
• Edward Morley - performed interferometry experiment with Michelson
• Ferid Murad - co-winner of the 1998 Nobel Prize in Physiology or Medicine, for discovering role of nitric oxide in cardiovascular signaling
• George A. Olah - winner of the 1994 Nobel Prize in Chemistry, for contributions to carbocation chemistry
• James Polshek - architect; designed William J. Clinton Presidential Library
• Edward C. Prescott - co-winner of the 2004 Nobel Prize in Economic Science, for theory on business cycles and economic policies
• Frederick Reines - co-winner of the 1995 Nobel Prize in Physics, for the detection of the neutrino
• Frederick C. Robbins - co-winner of the 1954 Nobel Prize in Physiology or Medicine, for work on polio virus, which led to development of polio vaccines; past president of the Institute of Medicine of the National Academy of Sciences
• David Satcher - U.S. Surgeon General under President Bill Clinton, and first African-American director of the Centers for Disease Control and Prevention (CDC)
• Jesse Leonard Steinfeld - U.S. Surgeon General (1969 to 1973), most noted for achieving widespread fluoridation of water, requiring prescription drugs to be effective, and strengthening the Surgeon General's Warning on cigarettes
• Earl W. Sutherland - winner of 1971 Nobel Prize in Physiology or Medicine, for establishing identity and importance of cyclic AMP in regulation of cell metabolism
• Peter Tippit - developed first anti-virus software, "Vaccine", later sold and renamed Norton AntiVirus

Arts and Entertainment

• Franklin Cover - actor; most noted role, Tom Willis in "The Jeffersons"
• Suzie Gharib - co-anchor of the "Nightly Business Report"
• Jack Perkins - dubbed "America's most literate correspondent" by the Associated Press; reporter, commentator, war correspondent, anchorman; seen on NBC's "Nightly News" and "The Today Show", and on A&E as host of "Biography"
• Alan Rosenberg - actor; most noted role, Ira Woodbine in "Cybill"; Emmy-nominated for guest appearance on " ER"
• Joe Russo & Anthony Russo - brothers, coalumni, and directors of "Pieces" and "Welcome to Collinwood"
• Alix Kates Shulman - author; best work Memoir of an Ex-Prom Queen, widely recognized as first important novel to emerge from women's liberation movement

Business/Philanthropy

• William F. Baker - President and CEO of public television's flagship station, Thirteen/WNET in New York
• Robert J. Herbold - Executive Vice President at Microsoft
• Barry Meyer - Chairman and CEO of Warner Bros (1999-present)
• Craig Newmark - founder of Craigslist
• Kent Hale Smith - founder of Lubrizol

Sports

• Michael McCaskey - Chairman of the board, Chicago Bears; son of George Halas, founder-owner-coach of Chicago Bears and record-holder of most games won (324) for nearly three decades--until broken by fellow alumnus Don Shula in 1993