The college has one main campus and five branch campuses:
- Southern and Dobson, in the western part of Mesa, Arizona, serves
the majority of the students
- Red Mountain, in northeast Mesa
- Williams Gateway, at Williams Gateway
- ASU Research Park, in south Tempe, Arizona
- Country Club and Brown, in downtown Mesa.
- Centennial Way, which specializes in business and industry classes, is also in downtown Mesa.
In addition, MCC offers classes over the Internet.