Centenary is a member of the NCAA Division I
Mid-Continential Athletic Conference. It has historically had a strong soccer program. The school is well-known for its basketball prominence in the late 1970s, and golf ability in the early 1980s. The school mascot is the gentleman; womens' sports' mascot is the lady.Centenary hosts six social fraternities and
sororities. However, the school hosts chapters of several academic honor organizations, including Omicron Delta Kappa,
Alpha Chi, and Sigma Tau Delta. The national
co-ed service fraternity Alpha
Phi Omega is also represented.